COVID-19 Discussion (No Politics)

I trust for UF.N you will show us the new fashion. You know, seeing is believing. Just post a Youtube video of you getting into and out of this “new suit.” :rofl:

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Hidden camera footage stolen. Best Naked Gun Condom GIFs | Gfycat

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Glad to see I’m not the only one who had that as a first thought. :joy:

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being alive is important if you want to keep living

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I’m one of the last group that received small pox vaccine. That is supposed to help with Monkey Pox. My wife, seven years younger, never received it.

A friend sent me this link. I read the Twitter thread quickly. This seems to be about an interesting study of long Covid. I haven’t read the study itself yet. It is here:

The @Annals!M link does not seem to work. A road to nowhere. Was able to see some stuff at AWG twitter post/thread.

@UtahFanSir, here is the link:

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Frankly I never saw that the VA in SLC evert dropped it’s mask requirement, and Ive been up at least once a month since January.

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They never did drop their mandate. That said, had they not shuttered the Blue Clinic at the beginning of the pandemic, maybe I don’t end up having all the medical issues I have had to deal with in 2022. Something tells me had I been able to get treatment for my infection in 2020, this all gets nipped in the bud. Then again, hindsight is 20/20.

May 28, 2022

U.S. doctors Reconsider Pfizer’s Paxlovid for Lower-risk COVID Patients

By Deena Beasley

May 28 (Reuters) - Use of Pfizer Inc’s (PFE.N) COVID-19 antiviral Paxlovid spiked this week, but some doctors are reconsidering the pills for lower-risk patients after a U.S. public health agency warned that symptoms can recur after people complete a course of the drug, and that they should then isolate a second time.

More quarantine time “is not a crowd-pleaser,” Dr. Sandra Kemmerly, an infectious disease specialist at Ochsner Health in New Orleans, told Reuters. “For those people who really aren’t at risk … I would recommend that they not take it.”

Use of Pfizer’s Paxlovid, authorized to treat newly infected, at-risk people in order to prevent severe illness, has soared as infections have risen. More than 162,000 courses were dispensed last week - compared with an average of 33,000 a week since the drug was launched late last year, according to government data. Biden administration officials have pushed for wide use of Paxlovid, which the government purchased and provides free.

But higher use has also come with more reports from people who say their symptoms eased with Paxlovid only to return a few days after finishing a five-day regimen of the pills.

On Tuesday, the Centers for Disease Control and Prevention, citing case reports and concerns that relapsed patients could spread the virus, issued its advisory that Paxlovid users should isolate for a second five days if symptoms rebound. read more

“I am shying away from giving it to people who are very low- risk, and are not terribly ill, particularly people who are vaccinated and boosted,” said Dr. Bruce Farber, chief of public health and epidemiology for Northwell Health. He said he is still recommending Paxlovid for people who have significant health conditions or are over age 75.

Pfizer, in an email, said it is monitoring the data, but believes the return of detectable virus is uncommon and not uniquely associated with its drug. “We have not seen any resistance emerge to date in patients treated with Paxlovid,” a spokesperson said.

Paxlovid’s emergency authorization stipulates that it should be used only for newly infected people with risk factors, but doctors said many others have sought out a prescription.

“We get a lot of requests - maybe somebody is traveling and they want to take it just in case,” said Dr. Tara Vijayan, infectious disease specialist at UCLA Health in Los Angeles. “We are not offering it as a just-in-case.”

The CDC also said it is unclear whether cases of rebound symptoms have anything to do with Paxlovid, or are simply part of the natural trajectory of COVID-19. The agency did not flag any specific concerns about health effects.

“COVID historically has had this sort of stuttering course - people will feel better one day and then feel worse the next day, but I can say we haven’t seen these rebound symptoms with other COVID treatments,” said Vijayan, referring to therapies such as monoclonal antibodies.

“The patients that do get a rebound, it’s usually very mild,” said Dr. Earl Strum, medical director of employee health at Keck Medicine of USC in Los Angeles.

Some question how much Paxlovid is helping given the high number of people vaccinated or previously infected with COVID-19. The drug was authorized in December after a study in unvaccinated, high-risk COVID patients with conditions like diabetes showed an 88% reduction in hospitalization or death.

At the time, the Delta variant was prevalent, but it has since been displaced by the more transmissible Omicron.

“There’s so much more baseline immunity around. There’s still a lot of infections, but they’re not nearly as severe,” Northwell’s Farber said.

He estimated the rate of Paxlovid-related COVID rebounds at around 10% - higher than the 3-4% rate cited by Pfizer in its trials of the drug.

Jason Gallagher, an infectious diseases expert at Temple University’s School of Pharmacy, said the rebounds do not detract from the drug’s utility. “It prevents you from going to the hospital … if you become symptomatic after you stop taking it, that stinks, but the overall drug was a success,” he said.

I took Paxlovid beginning on the day I was diagnosed with Covid. Within 3 hours of taking the first dose I experienced a noticeable improvement. Within 6 hours my epic sore throat was tamed and it diminished by 90% in the first 24 hours and was gone completely in 72. But no long Covid. No rebound of Covid. Likely I was not in the high risk group.

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Friends are telling me that more and more folks they know have gotten infected with Covid over the last handful of weeks. We’ve read it here among posters. Looks like this rise is nearing a plateau, but how knows, with the summer coming on and folks gathering.

Here is where the action is…

I watch this regularly and I think the lowest the daily mortality count got was in the low 300s, 309 or some number there. Note in the graph, the rate is now climbing, currently about 375. If that level of Covid mortality lasts for 12 months, the annual death toll will be between 110,000 and 140,000 folks, mostly the elderly or folks with an underlying health issue. To me that is still an unfortunately large number of our citizens.

Vaccination rates are shown next and where folks are vaccinated.

Deaths:

I don’t recall the risk of death between vaccinated and non-vaccintated, but it appears to me to be a no-brainer to get a vaccine since the likelihood of hospitalization and death is statistically so much lower.

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I just watched about 30 seconds of a video that a chiropractor friend of mine sent me of Russell Brand ranting about how it’s all a conspiracy between big pharma, governments, and the media. I can’t even ….

In the meantime another friend of mine tested positive yesterday morning and my step son at the VA is knocking himself out treating a new surge of patients, including some that don’t survive. Helluva hoax.

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Remember when we used to think Russell Brand was funny? Yeah, neither do I.

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More on the Paxlovid puzzle…

Coronavirus can be contagious during a Paxlovid rebound, researchers warn, even if people don’t have symptoms

By Brenda Goodman, CNN

May 31, 2022

(CNN)People who have a Covid-19 rebound after treatment with the antiviral drug Paxlovid can be contagious and may not know it because they might not have symptoms, researchers warn.

“People who experience rebound are at risk of transmitting to other people, even though they’re outside what people accept as the usual window for being able to transmit,” said Dr. Michael Charness of the Veterans Administration Medical Center in Boston.

Charness and his colleagues recently collaborated with a team of researchers at Columbia University to look into cases of Covid-19 that return after Paxlovid treatment. He said they’ve found at least two instances in which people have transmitted to others when their infection recurs.

In one case, a 67-year-old man infected a 6-month-old after a half-hour near the child.

The man was 12 days past his first positive Covid-19 test. He had taken a five-day course of Paxlovid and was feeling better. He didn’t have any symptoms when he saw the baby, who was his grandson, but about eight hours later, he started to feel ill again.

The baby tested positive about three days later, as did both of his parents. Neither the baby nor its parents had any other close contacts before they got sick.

“It indicates that you can transmit during rebound even before you develop symptoms,” Charness said. “And you know, we studied a small number of people. It’s certainly conceivable that there are other people out there who don’t have symptoms and still have a viral rebound.”

In another instance, a 63-year-old man infected two family members during three days of relapse after Paxlovid.

Take precautions after Paxlovid

Based on this research, the US Centers for Disease Control and Prevention issued new guidance last week for people experiencing Covid-19 rebound after Paxlovid.

The CDC said people who test positive again and whose symptoms come back after finishing their antiviral pills should restart their isolation period and isolate for five full days. The agency says people can end their isolation period after those five additional days as long as their fever has been gone for 24 hours without fever-reducing medication and they’re feeling better. The agency also recommends that people wear a mask for 10 days after their symptoms come back.

The findings and guidance come as Paxlovid use has increased in the United States. According the White House, over the past two months, filled prescriptions for Paxlovid have climbed from about 27,000 a week to 182,000 a week.

The administration credits the increase to its test-to-treat program, which created one-stop hubs in grocery and drug stores where people could take a Covid-19 test and immediately receive and fill a prescription for antiviral medications. The antiviral drugs should be taken within the first few days of symptoms.

The drug works well. In clinical trials, Paxlovid reduced the odds that a person at risk of severe Covid-19 would need to be hospitalized by almost 90% compared with a placebo.

For that reason, the CDC says, early treatment with this medication is still recommended.

As helpful as it is, though, researchers say people should be aware the drug may not completely extinguish the infection.

Charness and his co-authors have now collected at least 10 such cases of Covid-19 recurrence after Paxlovid. Half of them have come from just two families, leading the researchers to conclude that such cases are not all that rare.

The research is shared as a preprint. It has not been scrutinized by outside researchers or published in a medical journal.

Genetic testing suggests that when people get a second round of Covid-19 after Paxlovid, it’s not because they’ve been infected by a different strain of the virus. There’s also no sign that the virus has changed or mutated to develop some kind of resistance to the drug.

So far, rebound cases have been mild. There haven’t been any reports of severe disease during a Covid-19 relapse. Because of this, the CDC says, there’s no reason to think that more treatment is needed.

Cause still not known

Why this might be happening is still a mystery.

In his studies, Charness said, the researchers watched the amount of virus in a person’s body – called their viral load – go down on Paxlovid treatment.

“People take Paxlovid, and what we know it does very well is, it blocks viral replication,” he said. And so the levels of virus go down. But then in some people – no one knows how many, because not enough people have been studied – levels of the virus begin to climb again nine to 12 days after they first test positive, Charness said.

It’s not entirely clear that that rebound is linked to Paxlovid. In studies of more than 2,200 Covid-19 patients, Pfizer, the company that makes the drug, said there were a few patients who had their Covid-19 come bouncing back after a negative test, but they were in the group that took Paxlovid as well as in those who got the placebo, suggesting that Covid just reappears in some people, even without treatment.

Charness’ team has done its own comparison study, however, and found something different. When researchers looked at 1,000 cases of Covid-19 diagnosed between December and March in players and support staff of the National Basketball Association who had not taken the drug, they didn’t find any cases of Covid-19 returning. This study is still unpublished.

They say more research is needed to understand whether there could be any connection to the drug.

Charness said the fact that the infection can come back this way after treatment presents some questions. For one, would rebound be as common in people who started the drug later, maybe on day four or five after their first symptoms, after their immune systems have had longer to initially see the virus? Would a longer course of treatment – maybe taking the drug for six or seven days, rather than five – lower the risk that the virus would come back?

“No one knows,” he said. “Somebody should be studying this.”

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He was funny as the lead singer for infant sorrow.

I had no idea he was even around anymore.

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Looks like COVID will be our unwelcome guest for some time.

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I know as many people who currently have Covid as at the peak of the Omicron surge right now. I also sadly learned of a friend who passed away in February from it. I had no idea and reached out to her on Friday just to see how she was doing.

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Have a good friend who has sat with me at the men’s hoops games since the ending of the Boylen era and seldom misses a game (he attended every single game last season) Fully vaccinated but has come down with COVID (for very first time so has no anti-bodies) and says he’s feeling quite badly. Still at home and hopefully will recover soon.

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